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Literature summary extracted from

  • Lewin, A.; Hederstedt, L.
    Promoted evolution of a shortened variant of heme A synthase in the membrane of Bacillus subtilis (2008), FEBS Lett., 582, 1330-1334 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.17.99.9 DELTA211-217 Bacillus subtilis LMT20R is deleted for the ctaA gene and, therefore, completely blocked in heme A synthesis. Plasmid pH216MS is obtained from plasmid pH216M (encoding the mutant CtaA-H216M) and carries a 21 bp deletion in ctaA. The CtaADELTA211-217 variant encoded by pH216MS is active in heme A synthesis and supports assembly of normal levels of cytochrome caa3 Bacillus subtilis
1.17.99.9 H216M the H216M variant binds the enzyme substrate heme O, probably with methionine as an axial ligand, but is defective in heme A synthesis and accumulates a mono-hydroxylated reaction intermediate, heme I Bacillus subtilis
1.17.99.9 H216M/DELTA211-217 Bacillus subtilis LMT20R is deleted for the ctaA gene and, therefore, completely blocked in heme A synthesis. Plasmid pH216MS is obtained from plasmid pH216M (encoding the mutant CtaA-H216M) and carries a 21 bp deletion in ctaA. The CtaADELTA211-217 variant encoded by pH216MS is active in heme A synthesis and supports assembly of normal levels of cytochrome caa3 Bacillus subtilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.99.9 membrane membrane protein with 8 transmembrane segments Bacillus subtilis 16020
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Organism

EC Number Organism UniProt Comment Textmining
1.17.99.9 Bacillus subtilis P12946
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1.17.99.9 Bacillus subtilis 168 P12946
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Synonyms

EC Number Synonyms Comment Organism
1.17.99.9 ctaA
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 Bacillus subtilis